[Hinews] SEOUL, South Korea — A study led by Professor Sang-Hee Kang of Korea University Guro Hospital’s Colorectal Surgery Department reveals that age significantly affects the efficacy of adjuvant chemotherapy in colorectal cancer, with 70 years marking a pivotal threshold.

The research team examined data from 8,561 patients who underwent surgery for stage II or III colorectal cancer between 2014 and 2016 and received adjuvant chemotherapy. The focus was on oxaliplatin, a standard treatment for stage III patients and occasionally used for high-risk stage II cases.

(From left) Professors Sang-Hee Kang and Jun-Woo Bong, Department of Colorectal Surgery, Korea University Guro Hospital; Professors Seok-Song Jung and Hwa-Min Lee, Department of Biomedical Informatics, Korea University College of Medicine (Provided by Korea University Guro Hospital)
(From left) Professors Sang-Hee Kang and Jun-Woo Bong, Department of Colorectal Surgery, Korea University Guro Hospital; Professors Seok-Song Jung and Hwa-Min Lee, Department of Biomedical Informatics, Korea University College of Medicine (Provided by Korea University Guro Hospital)


Among stage III patients aged 70 or younger, oxaliplatin-based treatment yielded a five-year survival rate of 84.8%, notably higher than the 78.1% rate for those untreated with the drug. In contrast, patients over 70 showed minimal survival benefit, with higher rates of treatment discontinuation, likely due to oxaliplatin’s neurotoxic side effects.

For stage II patients, oxaliplatin offered no significant survival advantage, regardless of age.
“This study clearly shows that chemotherapy outcomes can differ by age,” Professor Kang stated. “For older patients, treatment should prioritize functional status and comorbidities over simplistic age-based guidelines.”

Conducted with support from the ICT Innovation Talent 4.0 project and Korea’s ARPA-H initiative, the study appeared in JAMA Network Open under the title “Older Age Threshold for Oxaliplatin Benefit in Stage II to III Colorectal Cancer.”

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